Electrophysiological Properties of Inferior Olive Neurons: A Compartmental Model
نویسندگان
چکیده
منابع مشابه
Electrophysiological properties of inferior olive neurons: A compartmental model.
As a step in exploring the functions of the inferior olive, we constructed a biophysical model of the olivary neurons to examine their unique electrophysiological properties. The model consists of two compartments to represent the known distribution of ionic currents across the cell membrane, as well as the dendritic location of the gap junctions and synaptic inputs. The somatic compartment inc...
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1. A model of the electrophysiological properties of single thalamocortical relay neurons in the rodent and cat dorsal lateral geniculate nucleus was constructed, based in part on the voltage dependence and kinetics of ionic currents detailed with voltage-clamp techniques. The model made the simplifying assumption of a single uniform compartment and incorporated a fast and transient Na+ current...
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Inferior olive (IO) neurons project to the cerebellum and contribute to motor control. They can show intriguing spatio-temporal dynamics with rhythmic and synchronized spiking. IO neurons are connected to their neighbors via gap junctions to form an electrically coupled network, and so it is considered that this coupling contributes to the characteristic dynamics of this nucleus. Here, we demon...
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In the cerebellar learning hypothesis, inferior olive neurons are presumed to transmit high fidelity error signals, despite their low firing rates. The idea of chaotic resonance has been proposed to realize efficient error transmission by desynchronized spiking activities induced by moderate electrical coupling between inferior olive neurons. A recent study suggests that the coupling strength b...
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Inferior olive neurons regulate plasticity and timing in the cerebellar cortex via the climbing fiber pathway, but direct characterization of the output of this nucleus has remained elusive. We show that single somatic action potentials in olivary neurons are translated into a burst of axonal spikes. The number of spikes in the burst depends on the phase of subthreshold oscillations and, theref...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 1999
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.1999.82.2.804